| 名称 |
Fluor 488 Anti-Human CD197/CCR7 Antibody[G043H7] |
| 来源 |
Mouse |
| 应用 |
FCM |
| 反应 |
Human |
| 克隆 |
G043H7 |
| 状态 |
Fluor 488 is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 520 nm (e.g., a 525/40 nm bandpass filter). |
| 亚型 |
Mouse IgG2a, κ |
| 基因ID |
1236 |
| 存储 |
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| 别名 |
EBI1; EVI1;CCR-7;CDw197;CMKBR7 |
| 背景介绍 |
CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis. |
