| 名称 |
PerCP/Cyanine5.5 Anti-Mouse/Rat Foxp3 Antibody[FJK-16s] |
| 来源 |
Rat |
| 应用 |
ICFCM |
| 反应 |
Mouse;Rat |
| 克隆 |
FJK-16s |
| 状态 |
PerCP/Cyanine5.5 is designed to be excited by the blue laser (488 nm) and detected using an optical filter centered near 675 nm (e.g., a 690/50 nm bandpass filter). |
| 亚型 |
Rat IgG2a, κ |
| 基因ID |
20371 |
| 存储 |
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| 别名 |
IPEX; JM2; Scurfin; Zinc finger protein JM2;Forkhead box protein P3 |
| 背景介绍 |
FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. |
