| 名称 |
anti- Phospho-VEGF Receptor 2-Y1175 antibody |
| 来源 |
Rabbit |
| 应用 |
ELISA, WB, IHC |
| 反应 |
Human, Mouse, Rat |
| 稀释范围 |
WB: 1:500 - 1:1000; IHC: 1:50 - 1:100 |
| 克隆 |
polyclonal |
| 蛋白号 |
P35968 |
| 分子质量 |
250 kDa |
| 纯化 |
Immunogen affinity purified |
| 纯度 |
≥95% as determined by SDS-PAGE |
| 状态 |
liquid |
| 免疫原 |
A phospho specific peptide corresponding to residues surrounding Y1175 of human VEGF Receptor 2 |
| 亚型 |
IgG |
| 存储 |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| 别名 |
CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGF Receptor 2, VEGFR, VEGFR 2, VEGFR2 |
| 背景介绍 |
KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas. |
