| 名称 |
anti- ILF3 antibody |
| 来源 |
Rabbit |
| 应用 |
ELISA, IHC, WB |
| 反应 |
Human, Mouse |
| 稀释范围 |
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| 克隆 |
polyclonal |
| 蛋白号 |
Q12906 |
| 分子质量 |
95/120 kDa |
| 纯化 |
Immunogen affinity purified |
| 纯度 |
≥95% as determined by SDS-PAGE |
| 状态 |
liquid |
| 免疫原 |
interleukin enhancer binding factor 3, 90kDa |
| 亚型 |
IgG |
| 存储 |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| 别名 |
DRBF, MPHOSPH4, NF90 |
| 背景介绍 |
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
