| 名称 |
anti- Caspase 1 antibody |
| 来源 |
Rabbit |
| 应用 |
ELISA, WB, IHC |
| 反应 |
Human, Mouse, Rat |
| 稀释范围 |
WB: 1:500-1:2000,IHC: 1:20-1:200 |
| 克隆 |
polyclonal |
| 蛋白号 |
P29466 |
| 分子质量 |
45-47 kDa, 30 kDa, 35 kDa |
| 纯化 |
Immunogen affinity purified |
| 纯度 |
≥95% as determined by SDS-PAGE |
| 状态 |
liquid |
| 免疫原 |
caspase 1, apoptosis-related cysteine peptidase(interleukin 1, beta, convertase) |
| 亚型 |
IgG |
| 存储 |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| 别名 |
CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, Interleukin 1 beta convertase, p10, p20, P45 |
| 背景介绍 |
CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta(IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing. |
