| 名称 |
anti- CASP14 antibody |
| 来源 |
Rabbit |
| 应用 |
ELISA, WB, IF |
| 反应 |
Human, Mouse, Rat |
| 稀释范围 |
WB: 1:500 - 1:2000; IF: 1:50 - 1:200 |
| 克隆 |
polyclonal |
| 蛋白号 |
P31944 |
| 分子质量 |
30 kDa |
| 纯化 |
Immunogen affinity purified |
| 纯度 |
≥95% as determined by SDS-PAGE |
| 状态 |
liquid |
| 免疫原 |
CASP14 |
| 亚型 |
IgG |
| 存储 |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| 别名 |
CASP14, ARCI12, caspase-14 |
| 背景介绍 |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. |
