| 名称 |
anti- ARHGEF1 antibody |
| 来源 |
Rabbit |
| 应用 |
ELISA, IHC, WB, IP |
| 反应 |
Human, Mouse |
| 稀释范围 |
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| 克隆 |
polyclonal |
| 蛋白号 |
Q92888 |
| 分子质量 |
102-110 kDa |
| 纯化 |
Immunogen affinity purified |
| 纯度 |
≥95% as determined by SDS-PAGE |
| 状态 |
liquid |
| 免疫原 |
Rho guanine nucleotide exchange factor(GEF) 1 |
| 亚型 |
IgG |
| 存储 |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| 别名 |
ARHGEF1, GEF1, LBCL2, LSC, P115 RHOGEF, p115RhoGEF, SUB1.5 |
| 背景介绍 |
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12(GNA12) and alpha-13(GNA13) subunits. Acts as GTPase-activating protein(GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor(GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. |
