CALP1

产品编号 HY-21222
产品分类 抑制剂
CAS号 145224-99-3
分子式 C40H75N9O10
分子量 842.09
品牌 华韵生物
规格 1mg 5mg
应用 CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site. It binds to calmodulin (Kd = 88 µM) and activates phosphodiesterase in the presence of calmodulin and absence of calcium. CALP1 also acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons thereby inhibiting excitatory cytotoxicity (IC50 = 52.48 µM) and apoptosis (IC50 = 44.78 µM). CALP1 (1mg/kg) pretreatment prevents increases in lung alveolar inflammatory cells after six, but not 24, hours in sensitized guinea pigs challenged with ovalbumin in a model of allergic asthma. It also decreases radical production induced by phorbol 12-myristate 13-acetatein broncho-alveolar lavage cells after six and 24 hours and dose-dependently decreases histamine-induced hyperresponsiveness in isolated guinea pig tracheal rings.
品牌 货号 纯度 规格 目录价(CNY) 会员价(CNY) 数量 购物车
华韵生物 HY-21222-1mg 1mg ¥5557.00
华韵生物 HY-21222-5mg 5mg ¥24902.00
COA查询 查询MSDS 大包装询盘
CAS号 145224-99-3
分子式 C40H75N9O10
分子量 842.09
纯度 ≥95%
状态 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。
存储 Pure form：
-20°C，3 years / 4°C，2 years ;
In solvent：
-80°C，6 months / -20°C，1 month ;
背景介绍 CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site. It binds to calmodulin (Kd = 88 µM) and activates phosphodiesterase in the presence of calmodulin and absence of calcium. CALP1 also acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons thereby inhibiting excitatory cytotoxicity (IC50 = 52.48 µM) and apoptosis (IC50 = 44.78 µM). CALP1 (1mg/kg) pretreatment prevents increases in lung alveolar inflammatory cells after six, but not 24, hours in sensitized guinea pigs challenged with ovalbumin in a model of allergic asthma. It also decreases radical production induced by phorbol 12-myristate 13-acetatein broncho-alveolar lavage cells after six and 24 hours and dose-dependently decreases histamine-induced hyperresponsiveness in isolated guinea pig tracheal rings.
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