ML115

产品编号 HY-18475
产品分类 抑制剂
CAS号 912798-42-6
分子式 C15H15ClN2O4
分子量 322.70
品牌 华韵生物
规格 500μg 1mg 5mg
应用 Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB. It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6. As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML115 may be useful in maintaining embryonic stem cells in an undifferentiated state.
品牌 货号 纯度 规格 目录价(CNY) 会员价(CNY) 数量 购物车
华韵生物 HY-18475-500μg 500μg ¥3071.00
华韵生物 HY-18475-1mg 1mg ¥5827.00
华韵生物 HY-18475-5mg 5mg ¥23073.00
COA查询 查询MSDS 大包装询盘
CAS号 912798-42-6
分子式 C15H15ClN2O4
分子量 322.70
纯度 ≥98%
状态 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。
存储 Pure form：
-20°C，3 years / 4°C，2 years ;
In solvent：
-80°C，6 months / -20°C，1 month ;
背景介绍 Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB. It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6. As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML115 may be useful in maintaining embryonic stem cells in an undifferentiated state.
暂无相关论文！
说明书更新中，请联系业务员索取！
暂无技术文章！
象形图
警示语
Class
警告声明
UNub
危险声明
Packing Group
搜索质检报告(COA)
相关产品
Cyclo(-D-Leu-D-Pro)
274680-11-4
Polyinosinic acid
30918-54-8
DSPE-PEG-CRGD
PEG6000
25322-68-3
PEG4000
25322-68-3
PEG500
25322-68-3
PEG200
25322-68-3
PEG1500
25322-68-3