PF-05105679

产品编号 HY-14024
产品分类 抑制剂
CAS号 1398583-31-7
分子式 C26H21FN2O3
分子量 428.46
品牌 华韵生物
规格 1mg 5mg 10mg
应用 PF-05105679 is an antagonist of transient receptor potential melastatin 8 (TRPM8; IC = 103 nM for inhibition of voltage-activated currents in HEK293 cells expressing the human receptor). It is greater than 100-fold selective for TRPM8 over a panel of 90 receptors, ion channels, and enzymes. PF-05105679 inhibits calcium flux induced by cold or the TRPM8 agonist WS-12 in HEK293 cells expressing the human TRPM8 (ICs = 480 and 181 nM, respectively). Intravenous infusion of PF-05105679 (46.67 μg/kg per minute) reverses cold-induced reductions in bladder capacity in anesthetized guinea pigs. It decreases the core body temperature in rats when administered at doses of 100 and 300 mg/kg.
品牌 货号 纯度 规格 目录价(CNY) 会员价(CNY) 数量 购物车
华韵生物 HY-14024-1mg 1mg ¥1968.00
华韵生物 HY-14024-5mg 5mg ¥7402.00
华韵生物 HY-14024-10mg 10mg ¥11812.00
COA查询 查询MSDS 大包装询盘
CAS号 1398583-31-7
分子式 C26H21FN2O3
分子量 428.46
纯度 ≥98%
状态 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。
存储 Pure form：
-20°C，3 years / 4°C，2 years ;
In solvent：
-80°C，6 months / -20°C，1 month ;
背景介绍 PF-05105679 is an antagonist of transient receptor potential melastatin 8 (TRPM8; IC = 103 nM for inhibition of voltage-activated currents in HEK293 cells expressing the human receptor). It is greater than 100-fold selective for TRPM8 over a panel of 90 receptors, ion channels, and enzymes. PF-05105679 inhibits calcium flux induced by cold or the TRPM8 agonist WS-12 in HEK293 cells expressing the human TRPM8 (ICs = 480 and 181 nM, respectively). Intravenous infusion of PF-05105679 (46.67 μg/kg per minute) reverses cold-induced reductions in bladder capacity in anesthetized guinea pigs. It decreases the core body temperature in rats when administered at doses of 100 and 300 mg/kg.
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